マブチ　ミユキ   MIYUKI MABUCHI   馬渕　美雪    所属   兵庫医科大学  薬学部 医療薬学科    職種   助教
言語種別	英語
発行・発表の年月	2015
形態種別	学術雑誌
標題	Improving the bioavailability and anticancer effect of the PCA-1/ALKBH3 inhibitor HUHS015 using sodium salt.
執筆形態	共著
掲載誌名	In vivo (Athens, Greece)
掲載区分	国外
巻・号・頁	29(1),pp.39-43
著者・共著者	Mabuchi Miyuki, Shimizu Tadashi, Ueda Masahiro, Sasakawa Yuka, Nakao Syuhei, Ueda Yuko, Kawamura Akio, Tsujikawa Kazutake, Tanaka Akito
概要	Prostate cancer antigen (PCA)-1/AlkB homologue 3 (ALKBH3) has been identified as a clinically significant factor and siRNA of PCA-1 inhibits DU145 proliferation both in vitro and in vivo. HUHS015 ( 1: ), a previous reported PCA-1 small-molecule inhibitor, was also effective without any obvious side-effects or toxicity. The potency of HUHS015, however, is not satisfying. We thought the reason is poor solubility of HUHS015 because insoluble material remained at the injection site after subcutaneous administration. To improve this inhibitor's solubility, we prepared various salts of HUHS015 and examined their solubility, which resulted in the selection of HUHS015 sodium salt ( 2: )
ISSN	1791-7549
PMID	25600528