マブチ ミユキ
  馬渕 美雪
   所属   兵庫医科大学  薬学部 医療薬学科
   職種   助教
言語種別 英語
発行・発表の年月 2017/04
形態種別 学術雑誌
査読 査読あり
標題 Systematic Trial for Evaluating Docetaxel in a Human Prostate Cancer Cell DU145 Xenograft Model.
執筆形態 共著
掲載誌名 Anticancer research
掲載区分国外
巻・号・頁 37(4),pp.1665-1676
著者・共著者 Mabuchi Miyuki, Ueda Masahiro, Yoshida Yuri, Horiike Kota, Yamaoka Kenta, Nakao Syuhei, Shimizu Tadashi, Ueda Yuko, Tsujikawa Kazutake, Tanaka Akito
概要 The inhibitory activities of docetaxel at a wide range of doses (0.1-10 mg/kg; subcutaneously (s.c.), once/week) in nude mice bearing a human prostate cancer cell (DU145), xenograft model with implantation of DU145 cells or a DU145 solid tumor were examined. This systematic trial demonstrated that (i) docetaxel was more effective in the xenograft model formed by implantation of DU145 cells than in the solid DU145 tumor; (ii) administration of 2.5 mg/kg docetaxel was the critical dose because inhibitory activities were not observed at 2.5 mg/kg, while they were noted at 5 mg/kg and 10 mg/kg in both implantation approaches; (iii) edema-like effects (plump body shape and legs) were observed in both groups at 2.5 mg/kg and the tumor sizes, often increased by blood plasma and other fluids, as well as body weights were higher than at other doses; and (iv) suppression of body weight gain was observed at 10 mg/kg docetaxel.
DOI 10.21873/anticanres.11496
ISSN 1791-7530
PMID 28373427