マブチ　ミユキ   MIYUKI MABUCHI   馬渕　美雪    所属   兵庫医科大学  薬学部 医療薬学科    職種   助教
言語種別	英語
発行・発表の年月	2000/06
形態種別	学術雑誌
査読	査読あり
標題	Stimulation of choleresis by insulin-like growth factor-I in rats.
執筆形態	共著
掲載誌名	Endocrine journal
掲載区分	国外
巻・号・頁	47(3),pp.249-55
著者・共著者	Kawamura I, Takeshita S, Fushimi M, Mabuchi M, Seki J, Tomoi M, Goto T
概要	IGF-I is an endogenous growth factor which is mainly produced in the liver. In the present study, the effect of IGF-I on bile flow and bile acid secretion was investigated in rats. In normal rats bile flow was significantly increased by single exogenous administration of IGF-I, and by 1 week treatment of IGF-I, both bile flow and bile acid secretion were significantly increased. We found that the decreases in bile flow and bile acid secretion observed in rats after hypophysectomy, as well as the decrease in the endogenous level of IGF-I in the blood, were partially reversed by 1 week exogenous IGF-I treatment. Overall, this study showed that IGF-I stimulates choleresis associated with an elevation of bile acid secretion in both normal and hypophysectomized rats when exogenously administered, suggesting the importance of IGF-I in the stimulation of choleresis in vivo.
DOI	10.1507/endocrj.47.249
ISSN	0918-8959
PMID	11036867