マブチ　ミユキ   馬渕　美雪    所属   兵庫医科大学  薬学部 医療薬学科    職種   助教
言語種別	日本語
発行・発表の年月	2001/05
形態種別	学術雑誌
査読	査読あり
標題	Induction of choleresis by immunosuppressant FK506 through stimulation of insulin-like growth factor-I production in the liver of rats.
執筆形態	共著
掲載誌名	European journal of pharmacology
掲載区分	国外
巻・号・頁	419(1),99-105頁
著者・共著者	Kawamura I, Takeshita S, Fushimi M, Mabuchi M, Seki J, Goto T
概要	FK506 (Tacrolimus) is an effective immunosuppressant currently used worldwide in organ transplantation. Based on our recent findings that insulin-like growth factor-I (IGF-I) is important for the stimulation of choleresis in vivo, in this study we investigated the effect of FK506 on bile flow and the plasma and hepatic levels of IGF-I in rats. Intravenous treatment of rats with FK506 resulted in a significant increase in bile flow, whereas cyclosporin A induced a significant decrease. A significant increase in plasma levels of IGF-I was observed in rats 30 min after a single intravenous administration of FK506. Oral treatment of rats with FK506 for 1 week also resulted in an increase in both plasma and hepatic levels of IGF-I. Overall, this study showed that FK506 treatment increased bile flow and also induced an increase in the plasma and hepatic levels of IGF-I in rats, suggesting that a stimulation of hepatic IGF-I production by FK506 may contribute to its choleretic profile.
DOI	10.1016/s0014-2999(01)00961-x
ISSN	0014-2999
PMID	11348636