マブチ　ミユキ   MIYUKI MABUCHI   馬渕　美雪    所属   兵庫医科大学  薬学部 医療薬学科    職種   助教
言語種別	日本語
発行・発表の年月	2003/06
形態種別	学術雑誌
査読	査読あり
標題	Insulin-like growth factor-I enhances choleretic action of FK506 in rats.
執筆形態	共著
掲載誌名	Transplantation proceedings
掲載区分	国外
巻・号・頁	35(4),1596-8頁
著者・共著者	Mabuchi M, Kawamura I, Takeshita S, Fushimi M, Takakura S, Hirosumi J, Mutoh S
概要	FK506 is an immunosuppressant for organ transplantation in the same clinical settings as cyclosporine (CsA). In the management of liver transplantation, FK506 has advantages over CsA, in terms of rejection and corticosteroid requirements. Recent clinical findings in liver transplant patients indicate that FK506, but not CsA, stimulates choleresis, suggesting that FK506 treatment may accelerate recovery from cholestatic dysfunction through its choleretic action. In this study, we evaluated the combined effect of treatment with both IGF-I and FK506 on bile flow in rats to explore the possibility that combination treatment in liver transplant patients could enhance the choleretic action of FK506, benefiting the transplanted liver. Overall, this study demonstrated that IGF-I treatment enhanced the choleretic action of FK506, providing potential clinical utility for combination therapy using these two drugs, in treatment after liver transplantation.
DOI	10.1016/s0041-1345(03)00358-0
ISSN	0041-1345
PMID	12826230