マブチ　ミユキ   MIYUKI MABUCHI   馬渕　美雪    所属   兵庫医科大学  薬学部 医療薬学科    職種   助教
言語種別	英語
発行・発表の年月	2003/07
形態種別	学術雑誌
標題	Choleretic actions of insulin-like growth factor-I, prednisolone, and ursodeoxycholic acid in rats.
執筆形態	共著
掲載誌名	Digestive diseases and sciences
掲載区分	国外
巻・号・頁	48(7),pp.1398-405
著者・共著者	Mabuchi Miyuki, Kawamura Ikuo, Fushimi Mariko, Takeshita Shigeru, Takakura Shoji, Hirosumi Jiro, Mutoh Seitaro
概要	A recent study by our group demonstrated that a 1-week infusion of insulin-like growth factor-I increases bile flow volume and bile acid secretion in rats, suggesting it is important in in vivo choleresis. In the present study, the effect in rats of a single administration of insulin-like growth factor-I on bile flow volume was investigated and compared with the choleretic drugs prednisolone and ursodeoxycholic acid. A significant and long-lasting increase in bile flow volume was observed in rats treated with insulin-like growth factor-I or prednisolone. Ursodeoxycholic acid significantly, but transiently increased. Combined treatment using insulin-like growth factor-I with prednisolone or ursodeoxycholic acid additively increased bile flow volume. Overall, this study demonstrated that the stimulatory effect of insulin-like growth factor-I indicating the possible therapeutic potential of insulin-like growth factor-I in cholestatic liver diseases.
DOI	10.1023/a:1024140116705
ISSN	0163-2116
PMID	12870804