マブチ　ミユキ   馬渕　美雪    所属   兵庫医科大学  薬学部 医療薬学科    職種   助教
言語種別	英語
発行・発表の年月	2005/09
形態種別	学術雑誌
標題	Ameliorating effect of FK614, a novel nonthiazolidinedione peroxisome proliferator-activated receptor gamma agonist, on insulin resistance in Zucker fatty rat.
執筆形態	共著
掲載誌名	European journal of pharmacology
掲載区分	国外
巻・号・頁	519(1-2),pp.182-90
著者・共著者	Minoura Hideaki, Takeshita Shigeru, Yamamoto Tadashi, Mabuchi Miyuki, Hirosumi Jiro, Takakura Shoji, Kawamura Ikuo, Seki Jiro, Manda Toshitaka, Ita Makoto, Mutoh Seitaro
概要	Effect of FK614, a novel nonthiazolidinedione PPAR gamma agonist, on glucose tolerance and insulin resistance in peripheral tissues and in liver using Zucker fatty rats was evaluated and compared to other insulin sensitizers. FK614 (0.32- 3.2 mg/kg), two thiazolidinedione PPAR gamma agonists, rosiglitazone (0.1-3.2 mg/kg) and pioglitazone (1-10 mg/kg), and a biguanide, metformin (320-1000 mg/kg), were orally administered to Zucker fatty rats once a day for 14 days. FK614 and rosiglitazone improved impaired glucose tolerance in Zucker fatty rats. In addition, FK614 dose-dependently ameliorated peripheral and hepatic insulin resistance in Zucker fatty rats. Metformin showed less potent effects than other insulin sensitizers and its effect in liver tended to be greater than that in peripheral tissues. These findings suggest clinical potential for FK614 as a treatment of type 2 diabetes, acting by ameliorating insulin resistance both in peripheral tissues and liver.
DOI	10.1016/j.ejphar.2005.05.042
ISSN	0014-2999
PMID	16039648