タカラ　コウジ   髙良　恒史    所属   兵庫医科大学  薬学部 医療薬学科    職種   准教授
言語種別	日本語
発行・発表の年月	2008/02
形態種別	大学・研究所等紀要
査読	査読あり
標題	Reversal effects of Ca2+ antagonists on multidrug resistance via down-regulation of MDR1 mRNA.
執筆形態	共著
掲載誌名	The Kobe journal of medical sciences
掲載区分	国内
巻・号・頁	53(6),355-63頁
著者・共著者	Komoto Chiho, Nakamura Tsutomu, Yamamori Motohiro, Ohmoto Nobuko, Kobayashi Hironao, Kuwahara Akiko, Nishiguchi Kohshi, Takara Kohji, Tanigawara Yusuke, Okamura Noboru, Okumura Katsuhiko, Sakaeda Toshiyuki
概要	In previous reports, the effects of 12 Ca2+ antagonists on a multidrug resistant transporter, P-glycoprotein/MDR1, were evaluated in terms of those on MDR1-mediated transport of [3H]digoxin and the sensitivity of vinblastine sulfate or paclitaxel, and they were able to be classified into 4 subgroups based on their actions, as those with transport inhibition and sensitivity recovery, those with or without transport inhibition but marginal sensitivity recovery, and those without both. In this study, our previous findings were confirmed by the resistance against doxorubicin hydrochloride and daunorubicin hydrochloride, and by the recovery of [3H] vinblastine sulfate accumulation. Furthermore, it was found that the effects of 12 Ca2+ antagonists on the sensitivity recovery were also explained by the down-regulation of MDR1 mRNA, suggesting a novel mechanism to reverse the MDR1-mediated multidrug resistance.
ISSN	1883-0498
PMID	18762730