タカラ コウジ
髙良 恒史 所属 兵庫医科大学 薬学部 医療薬学科 職種 准教授 |
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言語種別 | 日本語 |
発行・発表の年月 | 2004/10 |
形態種別 | 学術雑誌 |
査読 | 査読あり |
標題 | Effect of rabeprazole on MDR1-mediated transport of Rhodamine 123 in Caco-2 and Hvr100-6 cells. |
執筆形態 | 共著 |
掲載誌名 | Biological & pharmaceutical bulletin |
掲載区分 | 国内 |
巻・号・頁 | 27(10),1694-6頁 |
著者・共著者 | Itagaki Fumio, Homma Masato, Takara Kohji, Ohnishi Noriaki, Yokoyama Teruyoshi, Sakaeda Toshiyuki, Yagami Tatsurou, Kobayashi Hironao, Okamura Noboru, Kohda Yukinao |
概要 | The aim of our study was to investigate the effects of rabeprazole, a proton pump inhibitor, on MDR1 expressed on human colon carcinoma cell line, Caco-2, and MDR1-overexpressing human cervical carcinoma cell line, HeLa cells selected by exposure to 100 nM vinblastine (Hvr100-6 cells). Inhibitory effects of rabeprazole on MDR1-mediated transport of Rhodamine123 were examined in these cells. A thousand micro molar rabeprazole increased Rhodamine 123 uptakes in Caco-2 and Hvr100-6 cells by 68% and 185%, respectively. No significant effects of rabeprazole were observed at the concentration of 1-100 microM. Since rabeprazole did not show any effects on Rhodamine 123 transport via MDR1 at the plasma levels (approximately 1 microM), it was considered that the drug interaction with MDR1 substrates would be minimal even though the interaction occurred in the patients with rabeprazole treatment. |
DOI | 10.1248/bpb.27.1694 |
ISSN | 0918-6158 |
PMID | 15467223 |