タカラ　コウジ   髙良　恒史    所属   兵庫医科大学  薬学部 医療薬学科    職種   准教授
言語種別	日本語
発行・発表の年月	2017/09
形態種別	学術雑誌
標題	Pharmacokinetic Interaction Between Tacrolimus and Fentanyl in Patients Receiving Allogeneic Hematopoietic Stem Cell Transplantation.
執筆形態	共著
掲載誌名	Annals of transplantation
掲載区分	国外
巻・号・頁	22,575-580頁
著者・共著者	Kitazawa Fumiaki, Fuchida Shin-Ichi, Kado Yoko, Ueda Kumi, Kokufu Takatoshi, Okano Akira, Hatsuse Mayumi, Murakami Satoshi, Nakayama Yuko, Takara Kohji, Shimazaki Chihiro
概要	BACKGROUND Tacrolimus and fentanyl are well-known cytochrome P450 (CYP) 3A4 substrates with a narrow therapeutic range. However, the pharmacokinetic interaction between tacrolimus and fentanyl is unclear. The aim of this study was to determine whether drug interaction exists between tacrolimus and fentanyl. RESULTS The clearance (CL) of tacrolimus decreased significantly from 1.28 to 0.68 mL/min/kg with concomitant use of fentanyl. The CL changed with time and dose of fentanyl administration. In addition, the CL of tacrolimus was reverted by stopping fentanyl infusion. Horn's drug interaction probability scale indicated a probable category or possible category, suggesting a drug interaction between tacrolimus and fentanyl. No patient showed a difference in hepatic or renal function before and after fentanyl administration. No additional administration of other CYP3A4 inhibitors was observed, suggesting that the drug interaction was mediated by CYP3A4.
DOI	10.12659/aot.904505
ISSN	2329-0358
PMID	28947731