ハギハラ　カナコ   Hagihara Kanako   萩原　加奈子    所属   兵庫医科大学  薬学部 医療薬学科    職種   助教
言語種別	英語
発行・発表の年月	2017/07
形態種別	学術雑誌
査読	査読あり
標題	Identification of ACA-28, a 1'-acetoxychavicol acetate analogue compound, as a novel modulator of ERK MAPK signaling, which preferentially kills human melanoma cells.
執筆形態	共著
掲載誌名	Genes to cells : devoted to molecular & cellular mechanisms
掲載区分	国外
巻・号・頁	22(7),pp.608-618
著者・共著者	Satoh Ryosuke, Hagihara Kanako, Matsuura Kazuki, Manse Yoshiaki, Kita Ayako, Kunoh Tatsuki, Masuko Takashi, Moriyama Mariko, Moriyama Hiroyuki, Tanabe Genzoh, Muraoka Osamu, Sugiura Reiko
概要	Here, we carried out a chemical genetic screen using a fission yeast phenotypic assay and showed that ACA-28, a synthetic derivative of 1'-acetoxychavicol acetate (ACA), which is a natural ginger compound, effectively inhibited the growth of melanoma cancer cells wherein ERK MAPK signaling is hyperactivated due to mutations in the upstream activating regulators. ACA-28 more potently inhibited the growth of melanoma cells than did the parental compound ACA. Importantly, the growth of normal human epidermal melanocytes (NHEM) was less affected by ACA-28 at the same 50% inhibitory concentration. In addition, ACA-28 specifically induced apoptosis in NIH/3T3 cells which were oncogenically transformed with human epidermal growth factor receptor-2 (HER2/ErbB2), but not in the parental cells. ACA-28 might serve as a promising seed compound for melanoma treatment.
DOI	10.1111/gtc.12499
ISSN	1365-2443
PMID	28485554