ハギハラ　カナコ   Hagihara Kanako   萩原　加奈子    所属   兵庫医科大学  薬学部 医療薬学科    職種   助教
言語種別	英語
発行・発表の年月	2017/11
形態種別	学術雑誌
査読	査読あり
招待論文	招待あり
標題	A genome-wide screen for FTY720-sensitive mutants reveals genes required for ROS homeostasis.
執筆形態	共著
掲載誌名	Microbial cell (Graz, Austria)
掲載区分	国外
巻・号・頁	4(12),pp.390-401
著者・共著者	◎Hagihara Kanako, Kinoshita Kanako, Ishida Kouki, Hojo Shihomi, Kameoka Yoshinori, Satoh Ryosuke, Takasaki Teruaki, Sugiura Reiko
概要	Fingolimod hydrochloride (FTY720), a sphingosine-1-phosphate (S1P) analogue, is an approved immune modulator for the treatment of multiple sclerosis (MS). Here, we performed a genome-wide screening for genes whose deletion induces FTY720-sensitive growth in S. pombe and identified 49 genes. These gene products are related to the biological processes involved in metabolic processes, transport, transcription, translation, chromatin organization, cytoskeleton organization and intracellular signal transduction. Notably, most of the FTY720-sensitive deletion cells exhibited NAC-remedial FTY720 sensitivities and dysregulated ROS homeostasis. Our results revealed a novel gene network involving ROS homeostasis and the possible mechanisms of the FTY720 toxicity.
DOI	10.15698/mic2017.12.601
ISSN	2311-2638
PMID	29234668