ハギハラ　カナコ   Hagihara Kanako   萩原　加奈子    所属   兵庫医科大学  薬学部 医療薬学科    職種   助教
言語種別	英語
発行・発表の年月	2018/02
形態種別	学術雑誌
査読	査読あり
標題	Rae1-mediated nuclear export of Rnc1 is an important determinant in controlling MAPK signaling.
執筆形態	共著
掲載誌名	Current genetics
掲載区分	国外
巻・号・頁	64(1),pp.103-108
著者・共著者	Satoh Ryosuke, Hagihara Kanako, Sugiura Reiko
概要	In fission yeast, a KH-type RBP Rnc1 negatively regulates MAPK signaling activation via mRNA stabilization of the dual-specificity MAPK phosphatase Pmp1, which dephosphorylates MAPK Pmk1. Rnc1 also serves as a target of MAPK phosphorylation, which makes a feedback loop mediated by an RBP. We recently discovered that the nuclear export of Rnc1 requires mRNA-binding ability and the mRNA export factor Rae1. This strongly suggested the presence of an mRNA-export system, which recognizes the mRNA/RBP complex and dictates the location and post-transcriptional regulation of mRNA cargo. Here, we briefly review the known mechanisms of general nuclear transporting systems, with an emphasis on our recent findings on the spatial regulation of Rnc1 and its impact on the regulation of the MAPK signal transduction cascade.
DOI	10.1007/s00294-017-0732-5
ISSN	1432-0983
PMID	28799069