ハギハラ カナコ
Hagihara Kanako
萩原 加奈子 所属 兵庫医科大学 薬学部 医療薬学科 職種 助教 |
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言語種別 | 英語 |
発行・発表の年月 | 2012 |
形態種別 | 学術雑誌 |
査読 | 査読あり |
標題 | Sip1, a conserved AP-1 accessory protein, is important for Golgi/endosome trafficking in fission yeast. |
執筆形態 | 共著 |
掲載誌名 | PloS one |
掲載区分 | 国外 |
巻・号・頁 | 7(9),pp.e45324 |
著者・共著者 | Yu Yang, Kita Ayako, Udo Masako, Katayama Yuta, Shintani Mami, Park Kwihwa, Hagihara Kanako, Umeda Nanae, Sugiura Reiko |
概要 | Here, we isolated a mutant allele of its4(+)/sip1(+), which encodes a conserved AP-1 accessory protein. We found that Sip1 was a Golgi/endosomal protein and the sip1-i4 mutation affected AP-1 localization at Golgi/endosomes, thus indicating that Sip1 recruited the AP-1 complex to endosomal membranes by physically interacting with each subunit of this complex. Furthermore, Sip1 is required for the correct localization of Bgs1/Cps1, 1,3-β-D-glucan synthase to polarized growth sites. Taken together, our findings reveal a role for Sip1 in the regulation of Golgi/endosome trafficking in coordination with the AP-1 complex, and identified Bgs1, required for cell wall synthesis, as the new cargo of AP-1-dependent trafficking. |
DOI | 10.1371/journal.pone.0045324 |
ISSN | 1932-6203 |
PMID | 23028933 |