モリヤマ マサヒロ   MORIYAMA Masahiro
  森山 雅弘
   所属   兵庫医療大学  薬学部 医療薬学科
   兵庫医療大学  大学院薬学研究科 医療薬学専攻
   職種   教授
言語種別 日本語
発行・発表の年月 2016/09
形態種別 学術雑誌
査読 査読あり
標題 Correlation between blood magnesium and calcium concentration in patients treated with an anti-EGFR antibody.
執筆形態 共著
掲載誌名 Journal of pharmaceutical health care and sciences
掲載区分国内
巻・号・頁 2,23頁
著者・共著者 Tsujii Toshiyasu, Ogaki Takafumi, Nakae Kaori, Imai Kiyotaka, Kise Daisuke, Tada Shoji, Ueda Hiroki, Moriyama Masahiro
概要 BACKGROUND:Hypomagnesemia is one of the characteristic side effects of the human anti-epidermal growth factor receptor (EGFR) monoclonal antibodies, cetuximab and panitumumab. The major mechanism of anti-EGFR antibody-related hypomagnesemia is suppression of EGFR-mediated urinary Mg(2+) reabsorption in both the renal tubule the intestinal tract. Since Mg(2+) is known to affect blood Ca(2+) levels through regulation of parathyroid hormone (PTH) secretion, we investigated the correlation between Ca(2+) and Mg(2+) concentration in blood.
DOI 10.1186/s40780-016-0060-9
ISSN 2055-0294
PMID 27688901