コンノ　リエ   RIE KONNO   今野　理恵    所属   兵庫医科大学  看護学部 看護学科    職種   教授
言語種別	英語
発行・発表の年月	2023/05
形態種別	学術雑誌
査読	査読あり
標題	Incidence of severe infection in patients with rheumatoid arthritis taking biologic agents: a systematic review.
執筆形態	共著
掲載誌名	JBI evidence synthesis
掲載区分	国外
巻・号・頁	21(5),pp.835-885
総ページ数	30
著者・共著者	Makimoto Kiyoko, Konno Rie, Kinoshita Atsushi, Kanzaki Hatsumi, Suto Shunji
概要	OBJECTIVE: The objective of this review was to estimate the population-based incidence and determine the types of severe infection and deaths experienced by patients with rheumatoid arthritis taking biologic agents. INTRODUCTION: In recent years, the incidence of severe infection in patients with rheumatoid arthritis in Western nations has been determined by observational studies. RESULTS: Fifty-two studies from 21 countries reported severe infection rates associated with using 8 biologic agents, plus nonbiologic disease-modifying antirheumatic drugs. Meta-analysis was conducted for 8 biologic agents and conventional disease-modifying antirheumatic drugs. The meta-analysis revealed an infection rate of 5.0/100 person-years (95% CI 3.8-6.7) among patients receiving tumor necrosis factor inhibitors (heterogeneity 98.2%). The meta-analysis for the other 3 biologic agents revealed a point estimate of 5.5 to 8.7/100 person.
DOI	10.11124/JBIES-22-00048
ISSN	2689-8381
PMID	36630204