ハギハラ　カナコ   Hagihara Kanako   萩原　加奈子    所属   兵庫医科大学  薬学部 医療薬学科    職種   助教
言語種別	英語
発行・発表の年月	2018/03
形態種別	学術雑誌
査読	査読あり
招待論文	招待あり
標題	More than Just an Immunosuppressant: The Emerging Role of FTY720 as a Novel Inducer of ROS and Apoptosis.
執筆形態	共著
掲載誌名	Oxidative medicine and cellular longevity
掲載区分	国外
巻・号・頁	2018,pp.4397159
著者・共著者	Takasaki Teruaki, Hagihara Kanako, Satoh Ryosuke, Sugiura Reiko
概要	Fingolimod hydrochloride (FTY720) is a first-in-class of sphingosine-1-phosphate (S1P) receptor modulator approved to treat multiple sclerosis by its phosphorylated form (FTY720-P). In this review, we introduce our recent discoveries using a chemical genomics approach to uncover a signaling network relevant to FTY720-mediated ROS signaling and apoptosis, thereby proposing new potential targets for combination therapy as a means to enhance the antitumor efficacy of FTY720 as a ROS generator. We extend our knowledge by summarizing various measures targeting the vulnerability of cancer cells' defense mechanisms against oxidative stress. Future directions that may lead to the best use of FTY720 and ROS-targeted strategies as a promising cancer treatment are also discussed.
DOI	10.1155/2018/4397159
ISSN	1942-0994
PMID	29785244