ハギハラ　カナコ   Hagihara Kanako   萩原　加奈子    所属   兵庫医科大学  薬学部 医療薬学科    職種   助教
言語種別	英語
発行・発表の年月	2012
形態種別	学術雑誌
査読	査読あり
標題	Sip1, a conserved AP-1 accessory protein, is important for Golgi/endosome trafficking in fission yeast.
執筆形態	共著
掲載誌名	PloS one
掲載区分	国外
巻・号・頁	7(9),pp.e45324
著者・共著者	Yu Yang, Kita Ayako, Udo Masako, Katayama Yuta, Shintani Mami, Park Kwihwa, Hagihara Kanako, Umeda Nanae, Sugiura Reiko
概要	Here, we isolated a mutant allele of its4(+)/sip1(+), which encodes a conserved AP-1 accessory protein. We found that Sip1 was a Golgi/endosomal protein and the sip1-i4 mutation affected AP-1 localization at Golgi/endosomes, thus indicating that Sip1 recruited the AP-1 complex to endosomal membranes by physically interacting with each subunit of this complex. Furthermore, Sip1 is required for the correct localization of Bgs1/Cps1, 1,3-β-D-glucan synthase to polarized growth sites. Taken together, our findings reveal a role for Sip1 in the regulation of Golgi/endosome trafficking in coordination with the AP-1 complex, and identified Bgs1, required for cell wall synthesis, as the new cargo of AP-1-dependent trafficking.
DOI	10.1371/journal.pone.0045324
ISSN	1932-6203
PMID	23028933