タカラ　コウジ   髙良　恒史    所属   兵庫医科大学  薬学部 医療薬学科    職種   准教授
言語種別	日本語
発行・発表の年月	2004/10
形態種別	学術雑誌
査読	査読あり
標題	Effect of rabeprazole on MDR1-mediated transport of Rhodamine 123 in Caco-2 and Hvr100-6 cells.
執筆形態	共著
掲載誌名	Biological & pharmaceutical bulletin
掲載区分	国内
巻・号・頁	27(10),1694-6頁
著者・共著者	Itagaki Fumio, Homma Masato, Takara Kohji, Ohnishi Noriaki, Yokoyama Teruyoshi, Sakaeda Toshiyuki, Yagami Tatsurou, Kobayashi Hironao, Okamura Noboru, Kohda Yukinao
概要	The aim of our study was to investigate the effects of rabeprazole, a proton pump inhibitor, on MDR1 expressed on human colon carcinoma cell line, Caco-2, and MDR1-overexpressing human cervical carcinoma cell line, HeLa cells selected by exposure to 100 nM vinblastine (Hvr100-6 cells). Inhibitory effects of rabeprazole on MDR1-mediated transport of Rhodamine123 were examined in these cells. A thousand micro molar rabeprazole increased Rhodamine 123 uptakes in Caco-2 and Hvr100-6 cells by 68% and 185%, respectively. No significant effects of rabeprazole were observed at the concentration of 1-100 microM. Since rabeprazole did not show any effects on Rhodamine 123 transport via MDR1 at the plasma levels (approximately 1 microM), it was considered that the drug interaction with MDR1 substrates would be minimal even though the interaction occurred in the patients with rabeprazole treatment.
DOI	10.1248/bpb.27.1694
ISSN	0918-6158
PMID	15467223