タカラ　コウジ   髙良　恒史    所属   兵庫医科大学  薬学部 医療薬学科    職種   准教授
言語種別	日本語
発行・発表の年月	2012/03
形態種別	学術雑誌
査読	査読あり
標題	Differential effects of calcium antagonists on ABCG2/BCRP-mediated drug resistance and transport in SN-38-resistant HeLa cells.
執筆形態	共著
掲載誌名	Molecular medicine reports
掲載区分	国外
巻・号・頁	5(3),603-9頁
著者・共著者	Takara Kohji, Matsubara Mika, Yamamoto Kazuhiro, Minegaki Tetsuya, Takegami Shigehiko, Takahashi Minoru, Yokoyama Teruyoshi, Okumura Katsuhiko
概要	The effects of 9 calcium antagonists on ABCG2/BCRP-mediated resistance and transport were examined in HeLa and SN-38-resistant HeLa (HeLa/SN100) cells, overexpressing ABCG2/BCRP. Sensitivity to mitoxantrone, an ABCG2/BCRP substrate, in HeLa/SN100 cells was significantly reversed by the coexistence of the calcium antagonists, except for diltiazem and verapamil. The accelerated transport activity of Hoechst33342, an ABCG2/BCRP substrate, in HeLa/SN100 cells was significantly decreased by the presence of the calcium antagonists, except for diltiazem, nifedipine or verapamil, returning to the level of HeLa cells. The present study classifies the calcium antagonists into 3 categories: strong (benidipine, felodipine, nicardipine, nisoldipine and nitrendipine), moderate (amlodipine and nifedipine) and weak (diltiazem and verapamil) inhibitors of ABCG2/BCRP.
DOI	10.3892/mmr.2011.734
ISSN	1791-3004
PMID	22200670