マブチ　ミユキ   MIYUKI MABUCHI   馬渕　美雪    所属   兵庫医科大学  薬学部 医療薬学科    職種   助教
言語種別	日本語
発行・発表の年月	2004/06
形態種別	学術雑誌
査読	査読あり
標題	Pharmacological characteristics of a novel nonthiazolidinedione insulin sensitizer, FK614.
執筆形態	共著
掲載誌名	European journal of pharmacology
掲載区分	国外
巻・号・頁	494(2-3),273-81頁
著者・共著者	Minoura Hideaki, Takeshita Shigeru, Ita Makoto, Hirosumi Jiro, Mabuchi Miyuki, Kawamura Ikuo, Nakajima Satoko, Nakayama Osamu, Kayakiri Hiroshi, Oku Teruo, Ohkubo-Suzuki Akiko, Fukagawa Masao, Kojo Hitoshi, Hanioka Kenichi, Yamasaki Noritsugu, Imoto Takafumi, Kobayashi Yoshinori, Mutoh Seitaro
概要	We evaluated antidiabetic effects of FK614, a benzimidazole derivative without a thiazolidinedione structure, which was obtained using db/db mice. In db/db mice, the potency of FK614 for hypoglycemic effect was comparable to that of rosiglitazone and approximately 15-fold greater than that of pioglitazone. FK614 also showed a potent attenuating effect on hypertriglyceridemia in db/db mice, as well as rosiglitazone and pioglitazone. In ob/ob mice , ED(50) values of FK614 and pioglitazone for hypoinsulinemic effect were 1.3 and 11.8 mg/kg, respectively. FK614 also improved the impaired glucose tolerance in ob/ob mice. FK614 was found to activate PPAR gamma-mediated transcriptional activity in the reporter gene assay as well as thiazolidinedione derivatives, although its maximum effect was less than that of thiazolidinedione derivatives.
DOI	10.1016/j.ejphar.2004.04.038
ISSN	0014-2999
PMID	15212984